Combine Ingredients. In a medium bowl, whisk together ketchup, Worcestershire sauce, brown sugar, Dijon mustard, apple cider vinegar, garlic powder, and onion powder until smooth and fully blended.
Adjust Seasoning. Taste the sauce and adjust if needed. For more sweetness, add an extra teaspoon of brown sugar. For additional tang, add a splash more apple cider vinegar.
Store and Chill. Transfer the sauce to a jar or an airtight container. Refrigerate for at least 1 hour before serving to allow flavors to meld.
Serve. Use as a dipping sauce for steak, chicken, or burgers, or brush onto grilled meats as a finishing glaze.