Mix the Ingredients. In a large bowl, combine the ground bison, minced garlic, onion powder, salt, pepper, and Worcestershire sauce. Mix gently until the ingredients are just combined.
Form the Patties. Divide the mixture into equal portions and shape them into patties. Make a slight indentation in the center of each patty to prevent them from puffing up during cooking.
Preheat the Grill. Preheat your grill to medium-high heat. Clean and oil the grates to prevent sticking.
Grill the Patties. Place the bison patties on the grill and cook for about 4-5 minutes per side, or until they reach your desired level of doneness. Bison cooks faster than beef, so keep an eye on them.
Add Cheese. If using cheese, add a slice to each patty during the last minute of cooking and cover the grill to melt the cheese.
Toast the Buns. Lightly toast the hamburger buns on the grill until they’re golden and slightly crispy.
Assemble. Place the cooked bison patties on the bottom half of the buns. Top with your favorite toppings and condiments, then add the top bun.