In a large bowl, combine the shredded chicken, softened cream cheese, shredded cheese, salsa, taco seasoning, garlic powder, and onion powder. Mix until the filling is evenly combined and creamy.
Warm the corn tortillas so they become more pliable and less likely to crack when rolled. You can do this in the microwave wrapped in a damp paper towel or quickly in a skillet.
Spoon a small amount of filling onto each tortilla, then roll it up tightly. Place the seam side down so the taquito stays closed.
Lightly spray the rolled taquitos with olive oil spray. This helps them get golden and crisp as they cook.
Preheat the air fryer to 400°F. Place the taquitos in a single layer in the basket, seam side down, making sure not to overcrowd them. Cook until the tortillas are crisp and lightly browned.